DML
DML Sharif University of Technology
Mutational Network Analysis
Description
In this project network of co-mutations in breast cancer has been analyzed. By finding communities in co-mutational network groups of genes that are mutating together significantly in breast cancer patients have been founded. Many of these groups contains known cancer genes as well as novel genes. To validate out result pathway analysis has been done. Many of genes groups contains genes contributing in cancer related pathways. We also found that PPI interaction between genes of each group is significantly high. This study in this study can solve many unanswered questions about cancer and also is useful for multi target drug development.
Dataset
ICGC somatic mutations of breast cancer
Details
Start Date
Status
95%
Contributors
Hamid R. Rabiee
Fatemeh Hashemi Golpaygani
Morteza Kouhsar