DML Sharif University of Technology
Whole-Genome Analysis of De Novo Somatic Point Mutations Reveals Novel Mutational Biomarkers in Pancreatic Cancer
Many studies have identified cancer subtypes based on the cancer driver genes, or the proportion of mutational processes in cancer genomes, however, none of these cancer subtyping methods consider these features together to identify cancer subtypes. Accurate classification of cancer individuals with similar mutational profiles may help clinicians to identify individuals who could receive the same types of treatment. Here, we develop a new statistical pipeline and use a novel concept, “gene-motif”, to identify five pancreatic cancer subtypes, in which for most of them, targeted treatment options are currently available. More importantly, for the first time we provide a system-wide analysis of the enrichment of de novo mutations in a specific motif context of the driver genes in pancreatic cancer. By knowing the genes and motif associated with the mutations, a personalized treatment can be developed that considers the specific nucleotide sequence context of mutations within responsible genes.
ICGC Single Nucleotide Variations (SNV)
Hamid R. Rabiee
Amin Ghareyazi
Amir Mohseni
Hamed Dashti