DML
DML Sharif University of Technology
Evaluation of functional and structural networks of healthy Macaque monkey brains and comparison with Macaque monkeys with Parkinson's in previous research
Description
Parkinson's is a neurological disease that affects the function of different parts of the body. Despite the widespread effects of this disease on human motor functions and even decision-making, it is clear that it causes the most damage to the functional circuits of the brain. A new treatment recently proposed for this disease uses stem cell transplantation to repair damaged parts of the brain. This method has been implemented in non-human mammals (Macaque monkeys), and there is evidence that a complete cure for Parkinson's can be found. In this project, using rs-fMRI and DTI imaging techniques for functional and structural imaging of the brain network and by leveraging non-directional methods, we are trying to study and measure the brain circuits of five healthy Macaque monkeys. We will then compare the results of the evaluation of the brain circuits obtained from this step with the brain circuits reported from Parkinsonian Macaques in previous research. Ultimately, the difference between the two (healthy macaques and Parkinsonian ones) will help to understand the disease better. This is also the first step in confirming the treatment offered using stem cell injections. Finally, an important step can be taken to establish this treatment for human use by examining the above cases.
Dataset
fMRI and DTI taken from Macaque monkeys
Details
Start Date
Status
Sept. 22, 2020
30%
Contributors
Mohammad Ostadmohammadi
Hamid R. Rabiee
Gita Sarafraz
Matin Yousefabadi
Collaborators